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ntionalradiologistwithinsightintohowtoappropriatelyutlilisedifferenttechniquestooptimisethedinosis,treatmentandpalliationoftumours.Fullarticle(ThisarticlebelongstotheSpecialIssueInterventionalRadiology:TowardsPersonalizedMedicine)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,432KiB)20pes,3105KiB OpenAccessReviewBindingMoleculesinTickSalivaforTargetingHostCytokines,Chemokines,andBeyondbyChamberttanSouzaDesidério,VictorHugoPalharesFlávio-Reis,YoMarcosPessoa-Gonçalves,RafaelDestroRosaTiveron,HelioswiltonSales-Campos,AndreiGiacchettoFelice,SiomardeCastroSoares,RhainerGuillermo-Ferreira,WellingtonFranciscoRodriguesandCarloJoséFreireOliveiraBiomolecules2024,14(12),1647;doi.org/10.3390/biom(registering DOI)-21Dec2024AbstractTickshecoevolvedwiththeirhostsovermillionsofyears,developingtheabilitytoevadehemostatic,inflammatory,andimmunologicalresponses.Salivarymoleculesfromthesevectorsbindtocytokines,chemokines,antibodies,complementsystemproteins,vasodilators,andmoleculesinvolvedincoulationandplateletgregation,among[...]Readmore.Tickshecoevolvedwiththeirhostsovermillionsofyears,developingtheabilitytoevadehemostatic,inflammatory,andimmunologicalresponses.Salivarymoleculesfromthesevectorsbindtocytokines,chemokines,antibodies,complementsystemproteins,vasodilators,andmoleculesinvolvedincoulationandplateletgregation,amongothers,inhibitingorblockingtheiractivities.Initiallystudiedtounderstandthecomplexitiesoftick–hostinteractions,thesemoleculeshebeenmorerecentlyrecognizedfortheirpotentialclinicalapplications.Theirabilitytobindtosolublemoleculesandmodulateimportantphysiologicalsystems,suchasimmunity,hemostasis,andcoulation,positionsthemaspromisingcandidatesforfuturetherapeuticdevelopment.Thisreviewaimstoidentifythebindingmoleculespresentinticksaliva,determinetheirprimarytargets,andexplorethetickspeciesinvolvedintheseprocesses.Byassociatingthebindingmolecules,themoleculestowhichtheybind,andtheeffectcaused,thereviewprovidesabasisforunderstandinghowthesemoleculescancontributetopossiblefutureadvancesinclinicalapplications.Fullarticle(ThisarticlebelongstotheSpecialIssueCytokineSignalinginImmunityandImmuneCell-MediatedDiseases)9658;9660;ShowFiguresFigure1attachmentSupplementarymaterial:SupplementaryFile1(ZIP,105KiB)24pes,1250KiB OpenAccessSystematicReviewTheEffectofXanthineOxidaseInhibitorsinthePreventionandTreatmentofStroke:ASystematicReviewandMeta-AnalysisbyLinBai,GerhardLitscherandXiaoningLiJ.Cardiovasc.Dev.Dis.2024,11(12),409;doi.org/10.3390/jcdd(registering DOI)-21Dec2024AbstractBackground:Xanthineoxidaseinhibitors(XOIs)mayhelppreventstroke.However,heterogeneitycanbefoundintheconclusionsofdifferentstudies.Therelevantevidencewassummarizedinthissystematicreviewandmeta-analysistofurtherclarifytheroleofXOIsinthepreventionandtreatment[...]Readmore.Background:Xanthineoxidaseinhibitors(XOIs)mayhelppreventstroke.However,heterogeneitycanbefoundintheconclusionsofdifferentstudies.Therelevantevidencewassummarizedinthissystematicreviewandmeta-analysistofurtherclarifytheroleofXOIsinthepreventionandtreatmentofstroke,withafocusonevaluatingtheeffectsofXOIsinprimaryandsecondarypreventionofstroke,acutestroketreatment,andreductionofpost-strokecomplications.Methods:Randomizedcontrolledtrials(RCTs)orcohortstudiesontheeffectofXOIsinthepreventionandtreatmentofstrokeweresearchedinPubMed,EMBASE,andCochraneLibraryfrominceptionto3March2024,alongwithhandsearching.TheanalyseswerecarriedoutusingReviewManer5.4.Results:Theanalysisincluded14studies(115,579patients).WhileXOIsdidnotsignificantlyreducetheriskofstroke(RR:0.89;95%CI:0.59–1.34),theyimprovedpost-strokefunctionaloutcomes,withareductioninthemodifiedRankinscalescores(meandifference:−0.6;95%CI:−0.8to−0.4),decreasedintercellularadhesionmolecule-1levels(meandifference:−15.2ng/mL;95%CI:−22.3to−8.1),improvedaugmentationindex(AIx)by4.2%(95%CI:2.5–5.9%),reducedcentralbloodpressure(meanreduction:4.8mmHg;95%CI:2.6–6.9),anddelayedcarotidintima-mediathicknessprogression(meandifference:−0.05mm/year;95%CI:−0.08to−0.02).Fullarticle(ThisarticlebelongstotheSpecialIssueFeatureReviewPapersinStrokeandCerebrovascularDisease)20pes,9201KiB OpenAccessArticleImprovingArtStyleClassificationThroughDataAugmentationUsingDiffusionModelsbyMiguelÁngelMartínMoyano,IvánGarcía-uilar,EzequielLópez-RubioandRafaelM.Luque-BaenaElectronics2024,13(24),5038;doi.org/10.3390/electronics(registering DOI)-21Dec2024AbstractClassifyingpictorialstylesinartworksisacomplexchallengeduetothediversityandlackofailabledatasets,whichoftenlimittheperformanceofmachinelearningmodels.Toaddressthisissue,weproposeanoveldataaugmentationapproachusingDiffusionmodelsincontrast[...]Readmore.Classifyingpictorialstylesinartworksisacomplexchallengeduetothediversityandlackofailabledatasets,whichoftenlimittheperformanceofmachinelearningmodels.Toaddressthisissue,weproposeanoveldataaugmentationapproachusingDiffusionmodelsincontrasttotraditionalaugmentationtechniques.Ourmethodgeneratesnewsamplesbasedontheexistingdata,expandingtheailabledatasetandenhancingthegeneralizationcapabilityofclassificationmodels.Weevaluatetheeffectivenessofthisdataaugmentationtechniquebytrainingdeeplearningmodelswithvaryingproportionsofaugmentedandrealdataandassessingtheirperformanceinpictorialstyleclassification.OurresultsdemonstratethattheproposedDiffusionmodel-basedaugmentationsignificantlyimprovesclassificationaccuracy,suggestingthatitcanbeaviablesolutionforovercomingdatalimitationsinsimilarapplications.Fullarticle(ThisarticlebelongstotheSpecialIssueUsingDataAugmentationforVision-BasedDeepReinforcementLearning)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure621pes,3013KiB OpenAccessReviewLab-on-a-ChipDevicesforNucleicAcidAnalysisinFoodSafetybyInaeLeeandHae-YeongKimMicromachines2024,15(12),1524;doi.org/10.3390/mi(registering DOI)-21Dec2024AbstractLab-on-a-chip(LOC)deviceshebeendevelopedfornucleicacidanalysisbyintegratingcomplexlaboratoryfunctionsontoaminiaturizedchip,enablingrapid,cost-effective,andhighlysensitiveon-sitetesting.ThisreviewexaminestheapplicationofLOCtechnologyinfoodsafety,specificallyinthecontextof[...]Readmore.Lab-on-a-chip(LOC)deviceshebeendevelopedfornucleicacidanalysisbyintegratingcomplexlaboratoryfunctionsontoaminiaturizedchip,enablingrapid,cost-effective,andhighlysensitiveon-sitetesting.ThisreviewexaminestheapplicationofLOCtechnologyinfoodsafety,specificallyinthecontextofnucleicacid-basedanalysesfordetectingpathogensandcontaminants.Wefocusonmicrofluidic-basedLOCdevicesthatoptimizenucleicacidextractionandpurificationonthechiporamplificationanddetectionprocessesbasedonisothermalamplificationandpolymerasechainreaction.WealsoexploreadvancementsinintegratedLOCdevicesthatcombinenucleicacidextraction,amplification,anddetectionprocesseswithinasinglechiptominimizesamplepreparationtimeandenhancetestingaccuracy.Thereviewconcludeswithinsightsintofuturetrends,particularlythedevelopmentofportableLOCtechnologiesforrapidandefficientnucleicacidtestinginfoodsafety.Fullarticle(ThisarticlebelongstotheSpecialIssueAdvancesinMicrofluidicChipsforChemicalandBiomedicalApplications)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Scheme1attachmentSupplementarymaterial:SupplementaryFile1(ZIP,1161KiB)26pes,603KiB OpenAccessArticleGeneticVariantAnalysesIdentifyNovelCandidateAutismRiskGenesfromaHighlyConsanguineousCohortof104FamiliesfromOmanbyVijayGupta,AfifBen-Mahmoud,AhmedB.Idris,Jouke-JanHottenga,WesalHabbab,AbeerAlsayegh,Hyung-GooKim,WatfaAL-MamariandLawrenceW.StantonInt.J.Mol.Sci.2024,25(24),;doi.org/10.3390/ijms0(registering DOI)-21Dec2024AbstractDeficitsinsocialcommunication,restrictedinterests,andrepetitivebehioursarehallmarksofautismspectrumdisorder(ASD).Despitehighgeneticheritability,themajorityofclinicallydinosedASDcasesheunknowngeneticorigins.Weperformedgenomesequencingonmothers,fathers,andaffectedindividualsfrom104[...]Readmore.Deficitsinsocialcommunication,restrictedinterests,andrepetitivebehioursarehallmarksofautismspectrumdisorder(ASD).Despitehighgeneticheritability,themajorityofclinicallydinosedASDcasesheunknowngeneticorigins.Weperformedgenomesequencingonmothers,fathers,andaffectedindividualsfrom104familieswithASDinOman,aMiddleEasterncountryunderrepresentedininternationalgeneticstudies.Thisapproachidentified48novelcandidategenessignificantlyassociatedwithASDinOman.Inparticular,35ofthesegeneshebeenpreviouslyimplicatedinneurodevelopmentaldisorders(NDDs)inotherpopulations,underscoringtheconservedgeneticbasisofASDacrossethnicities.Geneticvariantswithinthesecandidategenesthatwouldimpacttheencodedproteinincluded1insertion,4frameshift,6splicing,12nonsense,and67missensechanges.Notably,61%oftheSNVswerehomozygous,suggestingaprominentrecessivegeneticarchitectureforASDinthisuniquepopulation.ThescarcityofgeneticstudiesonASDintheArabianPeninsulahasimpededtheunderstandingoftheuniquegeneticlandscapeofASDinthisregion.ThesefindingshelpbridgethisknowledgegapandprovidevaluableinsightsintothecomplexgeneticbasisofASDinOman.Fullarticle(ThisarticlebelongstotheSpecialIssueMolecularPhysiologicalandPathologicalProgressionofNeurologicalDiseases)36pes,8819KiB OpenAccessReviewHarnessingRadiationforNanotechnology:AComprehensiveReviewofTechniques,Innovations,andApplicationbyMobinulIslam,Md.ShahriarAhmed,SuaYun,Hae-YongKimandKyung-WanNamNanomaterials2024,14(24),2051;doi.org/10.3390/nano(registering DOI)-21Dec2024AbstractNanomaterialpropertiessuchassize,structure,andcompositioncanbecontrolledbymanipulatingradiation,suchasgammarays,X-rays,andelectronbeams.Thiscontrolallowsscientiststocreatematerialswithdesiredpropertiesthatcanbeusedinawiderangeofapplications,from[...]Readmore.Nanomaterialpropertiessuchassize,structure,andcompositioncanbecontrolledbymanipulatingradiation,suchasgammarays,X-rays,andelectronbeams.Thiscontrolallowsscientiststocreatematerialswithdesiredpropertiesthatcanbeusedinawiderangeofapplications,fromelectronicstomedicine.Thisuseofradiationfornanotechnologyisrevolutionizingthewaywedesignandmanufacturematerials.Additionally,radiation-inducednanomaterialsaremorecosteffectiveandenergyefficient.Thistechnologyisalsohingapositiveimpactontheenvironment,asmaterialsarebeingproducedwithfeweremissions,lessenergy,andlesswaste.Thiscutting-edgetechnologyisopeningupnewpossibilitiesandhasbecomeanattractiveoptionformanyindustries,frommedicaladvancementstoenergystore.Itisalsohelpingtomaketheworldabetterplacebyreducingourcarbonfootprintandpreservingnaturalresources.Thisreviewaimstometiculouslypointoutthesynthesisapproachandhighlightssignificantprogressingeneratingradiation-inducednanomaterialswithtunableandcomplexmorphologies.Thiscomprehensivereviewarticleisessentialforresearcherstodesigninnovativematerialsforadvancementsinhealthcare,electronics,energystore,andenvironmentalremediation.Fullarticle(ThisarticlebelongstotheSpecialIssueRadiationTechnologyinNanomaterials)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure9---Figure10---Figure11---Figure12---Figure13---Figure14---Figure15---Scheme1---Scheme2---Scheme3---Scheme4---Scheme5---Scheme6---Scheme7attachmentSupplementarymaterial:SupplementaryFile1(ZIP,378KiB)22pes,1171KiB OpenAccessArticleDiabeticNephropathy-AssociatedImpairedAorticFunctionIsNotMediatedbyMeanArterialPressureandItsDeterminantsbyHon-ChunHsu,MakabongweS’kholiweMazibuko,ChanelRobinson,NoluntuDlongolo,AngelaWoodiwiss,GloriaTeckie,GraceTadeandPatrickHectorDesseinJ.Clin.Med.2024,13(24),7827;doi.org/10.3390/jcm(registering DOI)-21Dec2024AbstractObjective:Thestudyaimedtoassessthepotentialimpactsofmeanarterialpressure(MAP)anditsdeterminants(cardiacoutputandsystemicvascularresistance)ondiabeticnephropathy(DNP)-associatedimpairedaorticfunction.Methods:Thismulti-ethnicstudyincluded115chronickidneydisease(CKD)patients(67non-dialysis[...]Readmore.Objective:Thestudyaimedtoassessthepotentialimpactsofmeanarterialpressure(MAP)anditsdeterminants(cardiacoutputandsystemicvascularresistance)ondiabeticnephropathy(DNP)-associatedimpairedaorticfunction.Methods:Thismulti-ethnicstudyincluded115chronickidneydisease(CKD)patients(67non-dialysisand48dialysis).SixaorticfunctionmeasureswereevaluatedbySpygmoCor.Thestrokevolumewasdeterminedbyechocardiography.Results:Hypertensivenephropathy(HNP)(53.9%),DNP(32.2%),glomerulonephritis(19.1%),andHIV-associatednephropathy(7.8%)composedthemajorCKDetiologies.ConcurrentHNPandDNPwerepresentin31.1%ofthepatients.ParticipantswithcomparedwiththosewithoutconcurrentHNPandDNPexperiencedmorefrequentestablishedcardiovasculardisease(43.2%versus14.9%,p=0.01),afasterpulsewevelocity(p=0.001),andsmallertotalarterialcomplianceasanindicatorofproximalaorticstiffness(p=0.03).DNPwasassociatedwitheachaorticfunctionmeasure(p<0.001–0.02)independentofpotentialconfoundersandMAP,aswellasitsdeterminants.HNPwasnotrelatedtoaorticfunction(p>0.05forallrelationships).MAPanditsdeterminantsdidnotmediatethepotentialimpactofDNPonaorticfunction(−4.1–6.4%contribution).CovariatesthatwereassociatedwithimpairedaorticfunctionmeasuresincludedMAPanditsdeterminants(p<0.001–0.01).Conclusions:MeanordistendingarterialpressureanditsdeterminantswereassociatedwithimpairedaorticfunctionintheoverallCKDpopulation.However,thesehemodynamicfactorsdidnotmediateDNP-associatedimpairedaorticfunction.OurresultssuggestthatbloodpressureloweringcanbeanticipatedtoimproveimpairedaorticfunctionintheoverallCKDpopulationbutnotwhenitissolelyinducedbyDNP.Fullarticle(ThisarticlebelongstotheSectionNephrology&Urology)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4attachmentSupplementarymaterial:SupplementaryFile1(ZIP,895KiB)23pes,KiB OpenAccessArticleC118PSuppressesGastricCancerGrowthviaPromotingAutophy–LysosomalDegradationofRAB1AbyShihuiWei,JingZhang,HaiWu,ZhengguangLiao,ZhengruiLiu,YuhangHou,DanyuDu,JingweiJiang,LiSun,ShengtaoYuanandMeiYangPharmaceutics2024,16(12),1620;doi.org/10.3390/pharmaceutics(registering DOI)-21Dec2024AbstractBackground/Objectives:Gastriccancer(GC)istheleadingcauseofcancer-relateddeathsworldwide.C118P,amicrotubuleinhibitorwithanti-angiogenicandvascular-disruptingactivities,wasproventobecytotoxictovariouscancercelllines.Thisstudyaimedtoexploretheanti-tumoreffectofC118Painst[...]Readmore.Background/Objectives:Gastriccancer(GC)istheleadingcauseofcancer-relateddeathsworldwide.C118P,amicrotubuleinhibitorwithanti-angiogenicandvascular-disruptingactivities,wasproventobecytotoxictovariouscancercelllines.Thisstudyaimedtoexploretheanti-tumoreffectofC118Painstgastriccancerandidentifyitspotentialtarget.Methods:TheMTTassay,colonyformationassay,andEdUincorporationassaywereusedtoevaluatetheeffectofC118PonGCcellproliferation.Cellcycleandcellapoptosisweremeasuredusingflowcytometry.Moleculardocking,amicroscalethermophoresis(MST)analysis,andthecellularthermalshiftassay(CETSA)wereusedtoinvestigatethebindingofC118PtoRAB1A.Autophy-relatedeffectswereevaluatedbyusingtheMDCstainingassay,immunofluorescenceassay,andimmunoblottingassay.TheSGC-7901celllinexenograftmousemodelwasusedtoconfirmtheanti-tumorefficacyofC118P.Results:C118Pdramaticallyinhibitedproliferation,inducedG2/Mcellcyclearrest,andtriggeredapoptosisinGCcelllinesHGC-27andSGC-7901.Mechanistically,C118PwasdemonstratedtobindwithRAB1AandreducetheRAB1Aproteinlevel,accompaniedbytheinhibitionofmTORC1signaling.Moreover,C118PinducedautophosomeformationandpromotedRAB1Aproteindegradationinanautophy–lysosomal-dependentmanner.TheinvivostudyverifiedthatC118PinhibitsGCgrowthbyinhibitingtheRAB1A-mTORaxis.Conclusions:OurfindingssuggestedthatC118PinhibitsGCgrowthbypromotingtheautophy–lysosomal-dependentdegradationofRAB1AandmodulatingmTORC1signaling.C118PshowspotentialasbeingasmallmoleculedrugeffectiveinthetreatmentofgastriccancerviatargetingRAB1A.Fullarticle(ThisarticlebelongstotheSectionDrugTargetingandDesign)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,1535KiB)23pes,3717KiB OpenAccessArticleInfluenceofYeastInteractionsontheFermentationProcessandAromaProductioninSyntheticCocoaPulpvs.RealMucileMediabyLydieBesançon,DaLorn,ChristelleKouamé,JoëlGrabulos,MarcLebrun,AngéliqueFontana,SabineSchorr-Galindo,RenaudBoulanger,CarolineStrubandAlexandreColasdelaNoueFermentation2024,10(12),662;doi.org/10.3390/fermentation(registering DOI)-21Dec2024AbstractCocoafermentationplaysakeyroleindefiningchocolate’sflor,withyeastsbeingcentraltothisprocess.Thisstudyaimedtoexploreintraspecificgeneticdiversityofmajorindigenousyeasts(i.e.,SaccharomycescerevisiaeandPichiakudrizevii),andtheirpotentialinteractioninthecocoa[...]Readmore.Cocoafermentationplaysakeyroleindefiningchocolate’sflor,withyeastsbeingcentraltothisprocess.Thisstudyaimedtoexploreintraspecificgeneticdiversityofmajorindigenousyeasts(i.e.,SaccharomycescerevisiaeandPichiakudrizevii),andtheirpotentialinteractioninthecocoapulpenvironment.Theirmetabolicintraspecificdiversitywascharacterizedinsyntheticcocoapulpmedium.Then,Saccharomycescerevisiae,Pichiakudrizevii,andotherstrainswereintroducedtoeachothertoevaluatetheirpotentialnegativeinteraction.Interestingstrainassociationswereselectedtofurtherexploretheirinteractioninsyntheticcocoapulpmediumaswellasrealfreshcocoapulp.FromafermentationcampaigninIvoryCoast,asetofSaccharomyces(S.)cerevisiaeandPichia(P.)kudrizeviistrainswereisolatedfrombatchesclassifiedaccordingtotheirchocolatequality(i.e.,standard,intermediate,orpremiumchocolate).Lessabundantspecies(i.e.,Torulasporafranciscae,Kluyveromycesmarxianus)werealsoisolatedandtestedfortheirpotentialnegativeinteractionswithS.cerevisiaeandP.kudrizevii.Asetofstrainswereselectedandculturedinsingleandinco-cultureinaminimalcocoapulpsyntheticmediumandinfreshcocoapulptohighlightpotentialpositiveand/ornegativeinteractionsregardingfermentativearomaprofile(i.e.,higheralcohols,acetateesters,medium-chainfattyacids,andethylesters).TheresultshighlightedthedominanceofS.cerevisiaeinfermentationkineticsandmedium-tolong-chainesterproduction,contrastedwithP.kudrizevii’sefficiencyinshort-chainestersynthesis.Intraspecificaromaprofilevariationscanbepointedout.Theco-culturesofP.kudrizeviiandS.cerevisiaestrainsisolatedfromthepremiumchocolatebatchhadapositiveimpactonthefermentedpulparomaprofile.NegativeinteractionswereobservedwithTorulasporafranciscae,whicheliminatedP.kudrizevii’saromaexpression.Finally,thecomparisonofthedataobtainedfortheminimalcocoapulpsyntheticmediumcomparedtothecocoapulpallowedustodrawconclusionsabouttheuseofsyntheticmediaforstudyingcocoafermentation.Thesefindingsemphasizethecomplexmicrobialinteractionsincocoafermentationthatcouldshapefuturecocoabeanaroma.Fullarticle(ThisarticlebelongstotheSpecialIssueDevelopmentandApplicationofStarterCultures,2ndEdition)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure619pes,876KiB OpenAccessReviewIncorporatingEnvironmentalSustainabilityandSupplyChainManementinContemporaryInteriorDesign:AStudyonChineseLandscapePaintingsbyJieMaandSafialAqbarBinZakariaBuildings2024,14(12),4071;doi.org/10.3390/buildings(registering DOI)-21Dec2024AbstractTheprimaryobjectiveofthisempiricalinvestigationwastocomprehensivelyexaminetheeconomic,environmental,andsocio-culturalfactorsthatexertasubstantialinfluenceonthecollectiveimpactofChineselandscapepaintingsandmodernistinteriordesign.Thestudyappliedacompleteeconometricframework,integratingunit[...]Readmore.Theprimaryobjectiveofthisempiricalinvestigationwastocomprehensivelyexaminetheeconomic,environmental,andsocio-culturalfactorsthatexertasubstantialinfluenceonthecollectiveimpactofChineselandscapepaintingsandmodernistinteriordesign.Thestudyappliedacompleteeconometricframework,integratingunitroottests,lselectioncriteria,andautoregressivedistributedl(ARDL)models.Theresultsindicateastatisticallysignificantandenduringassociationbetweenessentialfactors,suchascustomerdemand,priceelasticity,andsupplychaincosts.TheARDLmodelsdemonstratesignificantshort-termandlong-termeffects,asseenbythesubstantialR-squaredvaluesreaching84.4%.Thesefindingsconfirmthevariables’strengthandexplanatorycapabilityandincorporatestepwiseandrobustleastsquaresmodels,furthersupportingtheobtainedresults.Thepresentfindingsheimportantimplicationsforprofessionalsinvariousfieldsofartinteriordesign.Theresultsprovidevaluabledata-driveninsightsthatcaninformthecreationofsustainabilityandeconomicfeasibilityinthesedomains.Thisstudyisacrucialreferencepointforfutureacademicinquiriesandpracticalapplicationsintheinterdisciplinaryfieldsofart,design,andsupplychainmanement.Fullarticle(ThisarticlebelongstotheSectionArchitecturalDesign,UrbanScience,andRealEstate)9658;9660;ShowFiguresFigure1Figure2---Figure3attachmentSupplementarymaterial:SupplementaryFile1(ZIP,3001KiB)24pes,3330KiB OpenAccessArticleEvolution,StructuralandFunctionalCharacteristicsoftheMADS-boxGeneFamilyandGeneExpressionThroughMethylJasmonateRegulationinPanax ginsengC.A.MeyerbyKatlehoSenokoLephoto,DinghuiWang,SizhangLiu,LiLi,ChaofanWang,RuicenLiu,YueJiang,AiminWang,KangyuWang,MingzhuZhao,PingChen,YiWangandMeipingZhangPlants2024,13(24),3574;doi.org/10.3390/plants(registering DOI)-21Dec2024AbstractAbstract: MADS-boxgenesareessentialforplantdevelopmentandsecondarymetabolism.Themajorityofgeneswithinagenomeexistinagenefamily,eachwithspecificfunctions.Ginsengisanherbusedinmedicineforitspotentialhealthbenefits.TheMADS-Boxgene[...]Readmore.Abstract: MADS-boxgenesareessentialforplantdevelopmentandsecondarymetabolism.Themajorityofgeneswithinagenomeexistinagenefamily,eachwithspecificfunctions.Ginsengisanherbusedinmedicineforitspotentialhealthbenefits.TheMADS-BoxgenefamilyinJilinginsenghasnotbeenstudied.ThisstudyinvestigatedtheevolutionandstructuralandfunctionaldiversificationofthePgMADSgenefamilyusingbioinformaticsandanalyzedgeneexpressionthroughmethyljasmonate(MeJA)regulation.TheresultsrevealedthattheevolutionofthePgMADSgenefamilyisdivergedintotenclustersofaconstructedphylogenetictree,ofwhichtheSOC1clusteristhemostprevalentwithahighernumberofPgMADSgenes.Despitetheirdistinctevolutionaryclusters,asignificantnumberofmemberscontainscommonconservedmotifs.ThePgMADSgenefamilywasfunctionallydifferentiatedintothreeprimaryfunctionalcategories,biologicalprocess,molecularfunction,andcellularcomponent.Theirexpressionisvariablewithinatissue,atadevelopmentalste,andincultivars.RegardlessofthediversityofthefunctionsofPgMADSgenesandevolution,theirexpressioncorrelatedandformedaco-expressiongenenetwork.Weightedgeneco-expressionnetworkanalysesidentifiedhubgenesthatcouldberegulatingginsenosidebiosynthesis.Interestingly,thefamilyalsoisinvolvedinMeJAregulation.ThesefindingsprovideavaluablereferenceforfutureinvestigationsonPgMADSgenes.Fullarticle(ThisarticlebelongstotheSpecialIssueBioinformaticsandFunctionalGenomicsinModernPlantScience)15pes,1128KiB OpenAccessArticleHKAN:AHybridKolmogorov–ArnoldNetworkforRobustFabricDefectSegmentationbyMinLi,PeiYe,ShuqinCui,PingZhuandJunpingLiuSensors2024,24(24),8181;doi.org/10.3390/s(registering DOI)-21Dec2024AbstractCurrently,fabricdefectdetectionmethodspredominantlyrelyonCNNmodels.However,duetotheinherentlimitationsofCNNs,suchmodelsstruggletocapturelong-distancedependenciesinimesandfailtoaccuratelydetectcomplexdefectfeatures.WhileTransformersexcelatmodelinglong-rangedependencies,their[...]Readmore.Currently,fabricdefectdetectionmethodspredominantlyrelyonCNNmodels.However,duetotheinherentlimitationsofCNNs,suchmodelsstruggletocapturelong-distancedependenciesinimesandfailtoaccuratelydetectcomplexdefectfeatures.WhileTransformersexcelatmodelinglong-rangedependencies,theirquadraticcomputationalcomplexityposessignificantchallenges.Toaddresstheseissues,weproposecombiningCNNswithTransformersandintroduceKolmogorov–ArnoldNetworks(KANs)toenhancefeatureextractioncapabilities.Specifically,wedesignedanovelnetworkforfabricdefectsegmentation,namedHKAN,consistingofthreecomponents:encoder,bottleneck,anddecoder.First,wedevelopedasimpleyeteffectiveKANConvBlockusingKANconvolutions.Next,wereplacedtheMLPinPoolFormerwithKAN,creatingalightweightKANTransformerBlock.Finally,weunifiedtheKANConvBlockandtheKANTransformerBlockintoaHybridKANBlock,whichservesasboththeencoderandbottleneckofHKAN.ExtensiveexperimentsonthreefabricdatasetsdemonstratethatHKANoutperformsmainstreamsemanticsegmentationmodels,achievingsuperiorsegmentationperformanceanddeliveringprominentresultsacrossdiversefabricimes.Fullarticle(ThisarticlebelongstotheSectionFaultDinosis&Sensors)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure711pes,3801KiB OpenAccessArticleEffectofBiasVolteontheMicrostructureandPhotoelectricPropertiesofW-DopedZnOFilmsbyHaijuanMei,WanliWang,JunfengZhao,WeilongZhong,MuyiQiu,JiayangXu,KailinGao,GeLiu,JianchuLiangandWeipingGongNanomaterials2024,14(24),2050;doi.org/10.3390/nano(registering DOI)-21Dec2024AbstractW-dopedZnO(WZO)filmsweredepositedonglasssubstratesbyusingRFmnetronsputteringatdifferentsubstratebiasvoltes,andtherelationshipsbetweenmicrostructureandopticalandelectricalpropertieswereinvestigated.TheresultsrevealedthatthedepositionrateofWZOfilmsfirstdecreased[...]Readmore.W-dopedZnO(WZO)filmsweredepositedonglasssubstratesbyusingRFmnetronsputteringatdifferentsubstratebiasvoltes,andtherelationshipsbetweenmicrostructureandopticalandelectricalpropertieswereinvestigated.TheresultsrevealedthatthedepositionrateofWZOfilmsfirstdecreasedfrom8.8to7.1nm/min,andthenincreasedto11.5nm/minwiththeincreaseinbiasvolte.Afterapplyingabiasvoltetothesubstrate,thebombardmenteffectofsputteredionswasenhanced,andthefilmstransformedfromasmoothsurfaceintoacompactandroughsurface.Allthefilmsexhibitedahexonalwurtzitestructurewithastrong(002)preferredorientationandgrewalongthec-axisdirection.Whenthebiasvolteincreased,boththeresidualstressandlatticeparameterofthefilmsgraduallyincreased,andthemaximumgrainsizeof43.4nmwasachievedat−100Por favor, espere. NuvemV.Whenthebiasvoltewasbelow−300V,allthefilmsexhibitedahigheretransmittanceof~90%inthevisiblelightregion.Asthebiasvolteincreased,thesheetresistanceandresistivityofthefilmsinitiallydecreasedandthengraduallyincreased.ThehighestFOMof5.8×10−4Ω−1wasachievedat−100V,possessingthebestcomprehensivephotoelectricproperties.Fullarticle(ThisarticlebelongstotheSpecialIssueDesignandApplicationsofHeterogeneousNanostructuredMaterials)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,107KiB)12pes,730KiB OpenAccessArticleMacronutrientIntakeandFoodCategories’ContributiontoDailyEnergyIntakeAccordingtoBMIinPrimarySchoolChildreninCroatiabyLidijaŠoher,DanielaČačićKenjerić,MartinaPlić,IvanaRumbak,NatašaŠarlija,AnaIlićandDarjaSokolićNutrients2024,16(24),4400;doi.org/10.3390/nu(registering DOI)-21Dec2024AbstractBackground:Nutritionalstatusinchildhoodisassociatedwithanumberofshort-andlong-termhealtheffects.Therisingprevalenceofchildhoodobesityhighlightsthenecessityofunderstandingdietarypatternsinchildren.Thestudyprovidesanassessmentofenergyandmacronutrientintakeandfood[...]Readmore.Background:Nutritionalstatusinchildhoodisassociatedwithanumberofshort-andlong-termhealtheffects.Therisingprevalenceofchildhoodobesityhighlightsthenecessityofunderstandingdietarypatternsinchildren.Thestudyprovidesanassessmentofenergyandmacronutrientintakeandfoodcategories’contributiontoenergyintakeinCroatianprimaryschoolchildren,accordingtoBMIstatus.Methods:Toassessdietaryhabits,resultsoftheNationalFoodConsumptionSurveyonInfantsandChildrenbasedonEUMenumethodology(OC/EFSA/DATA/2016/02CT3)wereused.Thesampleincluded476children,ed6tounder10years.Results:Resultsindicatedthatoneinfourchildrenwasoverweightorobese(27.7%).Intotal,themeanenergyintakewas1598.4±380.3kcal/day,with30.7%ofthechildrenabovetherecommendedenergyintake.Cereals,cerealproducts,andpotatofoodcategoryweretheprimarysourcesofenergy,whichisinlinewiththerecommendations,withproteinandfatintakesexceedingrecommendedlevels.SubstantialcontributionofsweetsandlowcontributionoffruitsandvegetableswereobservedacrossallBMIcategories,withthedifferenceinenergycontributionoffruits(p=0.041)andvegetables(p=0.033).Themeat,poultry,fish,andeggscategorywerethecontributorstoenergyintakefromproteinandfat,inthemajorityofBMIgroups.Conclusions:Intheobesegroup,higherenergyintakefromcertainfoodsubgroupswasrecorded,stressingtheneedforamoredetaileddietaryassessment.Thestudy’scross-sectionaldesignlimitscausalinferences,indicatinganeedforfuturelongitudinalresearchtobetterunderstandthedynamicsofdietarypatternsandBMIstatusinprimaryschoolchildren.Fullarticle(ThisarticlebelongstotheSectionPediatricNutrition)9658;9660;ShowFiguresFigure114pes,4415KiB OpenAccessArticleAGreenComputingBusinessgregationStrategyforLowEarthOrbitSatelliteNetworksbyBoWang,JiaqiLv,DongyanHuang,ZelinLuandYuhangFangSensors2024,24(24),8184;doi.org/10.3390/s(registering DOI)-21Dec2024AbstractThispaperproposesagreencomputingstrategyforlowEarthorbit(LEO)satellitenetworks(LSNs),addressingenergyefficiencyanddelayoptimizationindynamicandenergy-constrainedenvironments.ByintegratingaMarkovDecisionProcess(MDP)withaDoubleDeepQ-Network(DoubleDQN)andintroducingthe[...]Readmore.ThispaperproposesagreencomputingstrategyforlowEarthorbit(LEO)satellitenetworks(LSNs),addressingenergyefficiencyanddelayoptimizationindynamicandenergy-constrainedenvironments.ByintegratingaMarkovDecisionProcess(MDP)withaDoubleDeepQ-Network(DoubleDQN)andintroducingtheEnergy–DelayRatio(EDR)metric,thisstudyeffectivelyquantifiesandbalancesenergysingswithdelaycosts.Simulationsdemonstratesignificantenergysings,withreductionsofupto47.87%underlowbusinessvolumes,accompaniedbyaminimaldelayincreaseofonly0.0161s.Formediumbusinessvolumes,energysingsreach26.75%,withadelayincreaseof0.0189s,whilehighbusinessvolumesachievea4.36%energyreductionandadelayincreaseof0.0299s.Theseresultshighlighttheproposedstrategy’sabilitytoeffectivelybalanceenergyefficiencyanddelay,showcasingitsadaptabilityandsuitabilityforsustainableoperationsinLEOsatellitenetworksundervaryingtrafficloads.Fullarticle(ThisarticlebelongstotheSectionCommunications)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure635pes,936KiB OpenAccessReviewNovelMolecularClassificationofBreastCancerwithPETImingbyNgôMinhToànMedicina2024,60(12),2099;doi.org/10.3390/medicina(registering DOI)-21Dec2024AbstractBreastcancerisaheterogeneousdiseasecharacterizedbyawiderangeofbiomarkerexpressions,resultinginvariedprogression,behior,andprognosis.Whiletraditionalbiopsy-basedmolecularclassificationisthegoldstandard,itisinvasiveandlimitedincapturingtumorheterogeneity,especiallyindeepor[...]Readmore.Breastcancerisaheterogeneousdiseasecharacterizedbyawiderangeofbiomarkerexpressions,resultinginvariedprogression,behior,andprognosis.Whiletraditionalbiopsy-basedmolecularclassificationisthegoldstandard,itisinvasiveandlimitedincapturingtumorheterogeneity,especiallyindeepormetastaticlesions.Moleculariming,particularlypositronemissiontomography(PET)iming,offeringanon-invasivealternative,potentiallyplaysacrucialroleintheclassificationandmanementofbreastcancerbyprovidingdetailedinformationabouttumorlocation,heterogeneity,andprogression.Thisnarrativereview,whichfocusesonbothclinicalpatientsandpreclinicalstudies,exploresthelatestadvancementsinPETimingforbreastcancer,emphasizingthedevelopmentofnewtracerstargetinghormonereceptorssuchastheestrogenalphareceptor,progesteronereceptor,androgenreceptor,estrogenbetareceptor,aswellastheErbBfamilyofreceptors,VEGF/VEGFR,PARP1,PD-L1,andmarkersforindirectlyassessingKi-67.Theseinnovativeradiopharmaceuticalshethepotentialtoguidepersonalizedtreatmentapproachesbasedontheuniquetumorprofilesofindividualpatients.Additionally,theymayimprovetheassessmentoftreatmentefficacy,ultimatelyleadingtobetteroutcomesforthosedinosedwithbreastcancer.Fullarticle(ThisarticlebelongstotheSectionOncology)9658;9660;ShowFiguresFigure119pes,3768KiB OpenAccessArticleSynergyBetweenMicrobialInoculantsandMineralFertilizationtoEnhancetheYieldandNutritionalQualityofMaizeonthePeruvianCoastbyRuthLópez-Montañez,EmileeCalero-Rios,KenyiQuispe,LuceroHuasasquiche,SphyrosLastra,BraulioLaTorreandRichardSolórzanoAppl.Microbiol.2024,4(4),1757-1775;doi.org/10.3390/applmicrobiol(registering DOI)-21Dec2024AbstractHardyellowmaizeisacrucialcropinPeruvianriculturethatplaysasignificantroleinfoodsecurityandlivestockproduction.However,intensivefertilizationpracticesinronomicmanementhenegativelyimpactedsoilhealth.Toexploremoresustainablericulturaltechnologies,researchersinvestigatedsolutionsusing[...]Readmore.HardyellowmaizeisacrucialcropinPeruvianriculturethatplaysasignificantroleinfoodsecurityandlivestockproduction.However,intensivefertilizationpracticesinronomicmanementhenegativelyimpactedsoilhealth.Toexploremoresustainablericulturaltechnologies,researchersinvestigatedsolutionsusingmicroorganismstoenhanceplantgrowth.ThisstudyassessedthesynergisticeffectsofmicrobialinoculantsandmineralfertilizationonINIA619andDekalB-7088maizevarieties’yieldandnutritionalquality.Asplit-plotdesignwasemployed,incorporatingfourinoculationtreatments—noinoculant,Bacillussubtilis,Trichodermaviride,andPseudomonasputida—combinedwithfertilizationlevelsof0%,50%,75%,and100%.ThefindingsrevealedthatBacillussubtilisboostedyieldsby13.1%inINIA619and55.5%inDekalB-7088.Additionally,combinedwith100%fertilization,microbialinoculationincreasedproteincontentby47%andcarbohydratesby6%inINIA619whilemaintainingnutritionalqualitywith75%fertilization.Similarly,inDekalB-7088,inoculationwithtotalfertilizationenhancedproteincontentby54%andfiberby27%.Theseresultsdemonstratedthatmicrobialinoculationcouldreducemineralfertilizationbyupto25%whilesustaininghighyieldsandimprovingthenutritionalqualityofmaize.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure8---Figure918pes,5935KiB OpenAccessArticleNumericalSimulationsofStressIntensityFactorsandFatigueLifeinL-ShapedSheetProfilesbyFerdinandDömling,FlorianPaysanandEricBreitbarthMetals2024,14(12),1463;doi.org/10.3390/met(registering DOI)-21Dec2024AbstractTheassessmentoffatiguecracksisanelementarypartofthedesignprocessoflightweightstructuressubjecttooperationalloads.Althoughangledsheetsarestandardcomponentsinformingtechnology,fatiguecrackgrowthingeometrieslikeC-andL-sectionshasbeenlittle-studiedandis[...]Readmore.Theassessmentoffatiguecracksisanelementarypartofthedesignprocessoflightweightstructuressubjecttooperationalloads.Althoughangledsheetsarestandardcomponentsinformingtechnology,fatiguecrackgrowthingeometrieslikeC-andL-sectionshasbeenlittle-studiedandismostlylimitedtocrackgrowthbeforethetransitionthroughthecorner.Inthisstudy,fatiguecrackpropationissimulatedtoexploretheinfluenceofsheetthickness,cornerangleandcornerradiusonthefatiguelifeinanL-section.Thestressintensityfactor(SIF)isderivedasthedrivingforceofcrackgrowthoverthefullcrackpath.SpecialattentionispaidtotheevolutionoftheSIFintheradiussub-sectionanditsimplicationsonthefatiguelife.TheresultsshowthattheSIFinanangledsheetforgivenloadingconditionsandcracklengthscannotbereadilyapproximatedbytheSIFinanequivalentstraightenedsheet.Thebendingangleandradiusleadtocrackgrowthretardationoraccelerationeffects.Thesefindingsareimportantforthedesignandoptimizationofforminggeometrieswithregardtofatiguecrackgrowth.Fullarticle(ThisarticlebelongstotheSpecialIssueFractureandFatigueofAdvancedMetallicMaterials)9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure5---Figure6---Figure7---Figure816pes,794KiB OpenAccessArticleAnalysisofGrowthModelsinGalician×NeloreCrossbredCattleintheFirstYearofLifebyAntonioIglesias,FernandoMata,JoaquimLimaCerqueira,AlicjaKowalczyk,JesúsCantalapiedra,JoséFerreiroandJoséAraújoAnimals2024,14(24),3698;doi.org/10.3390/ani(registering DOI)-21Dec2024AbstractThevealnichemarketisgainingmomentuminBrazil.Locallyknownas‘Vitelão’,vealreferstothemeatfromcalvesslaughteredupto12monthsofe.Inthisstudy,weassessedtheGalicianBlond×Nelorecrossasacandidatetoproduce[...]Readmore.ThevealnichemarketisgainingmomentuminBrazil.Locallyknownas‘Vitelão’,vealreferstothemeatfromcalvesslaughteredupto12monthsofe.Inthisstudy,weassessedtheGalicianBlond×Nelorecrossasacandidatetoproduceveal.Theaimofthisstudywastoestablishcriteriaforselecting12-month-oldcalvessuitableforslaughter.Tofindthebestfit,weadjustedvariousgrowthmodelsforcalvesupto12monthsofe.Oncethebestfitwasdetermined,theselectedgrowthmodelwasthenusedtocalculatetherelativeandinstantaneousgrowthratestoevaluatetheslaughteringpotentialat12months.Ourstudyrevealsthat,underpresentconditions,theLogisticmodelisthebestfitforcharacterizingandfunctionallyanalyzinggrowthfrombirthto12monthsofeinGalicianBlondcrosseswithNelore.Calvesresultingfromthiscrossexperiencerapidgrowthintheirfirst12monthsoflife,makingthemanexcellentchoiceforproducinghigh-qualityvealwhilemaintainingrusticityandadaptabilitytoextremeenvironments.TheresultsofthisstudycouldcontributetoenhancingthegrowthmanementsystemsofGalicianBlondandNelorecrossesinBraziliangrazingproductionsystems.Additionally,theycanbeincorporatedintogeneticimprovementprogramsasatoolforselectinganimalswithgreaterprecociousgrowthwithoutalteringadultweight.Fullarticle(ThisarticlebelongstotheSpecialIssueNewDevelopmentsinLivestockProductionSystems:ImprovingMeatProduction)19pes,3607KiB OpenAccessArticleMassSpectrometricBasedMetabolomicsoftheSaudiCultivarofFenugreek(Trigonellafoenum-graecumL.):ACombinedGC-MS,AntimicrobialandComputationalApproachbyNujudA.M.Almuzaini,AbdelMoneimE.Sulieman,NaimahA.Alanazi,RiadhBadraouiandEmadM.AbdallahPharmaceuticals2024,17(12),1733;doi.org/10.3390/ph(registering DOI)-21Dec2024AbstractBackgroundandObjective:InSaudiArabia,numerousplantspecieswithpromisingmedicinalpropertiesarecultivated,widelytraded,andcommonlyutilizedintraditionalmedicine,includingfenugreek(Trigonellafoenum-graecum).Thisstudyaimedtocomprehensivelyassessthephytochemicalcompositionandantimicrobialpotentialofthe[...]Readmore.BackgroundandObjective:InSaudiArabia,numerousplantspecieswithpromisingmedicinalpropertiesarecultivated,widelytraded,andcommonlyutilizedintraditionalmedicine,includingfenugreek(Trigonellafoenum-graecum).ThisstudyaimedtocomprehensivelyassessthephytochemicalcompositionandantimicrobialpotentialoftheSaudicultivaroffenugreekusinganintegrativeapproachcombininginvitroandinsilicomethodologies.Methods:Acomprehensiveinvestigationwasconductedontheethanolextractoffenugreekseeds,assessingitsantibacterial,antifungal,properties.Computationalmodelingwasemployedtopredictpharmacokineticbehiorandpotentialtoxicityoftheidentifiedbioactivecompounds.Results:Qalitativephytochemicalanalysisshowedpresenceofalkaloids,tannins,saponins,glycosides,flonoids,andsteroids,whileterpenoidswerenotablyabsent.GC-MSanalysisofTrigonellafoenum-graecum(fenugreek)seedsidentified25bioactivecompounds,withEthylmethanesulfonate(12.41%)beingthepredominantcomponent.Otherkeycompoundsincludedn-Hexadecanoicacid,4-Butyl-2(4-nitrophenyl)-1,3-thiazole,andα-Tocopherol.Insilicomodelingoffenugreekphytochemicalssupportedtheirantibacterial,antioxidant,andneuroprotectivepotential,withcompounds21and24showingstrongbindingtokeytargetslikeTyrosyl-tRNASynthetase(TyrRS)ofStaphylococcusaureus(S.aureus),AsparticproteinasefromCandidaalbicans(C.albicans)andhumanperoxiredoxin5.Pharmacokineticanalysisindicatedgoodoralbioailability,minimalCYPinhibition,andblood-brainbarrierpenetration,suggestingpotentialfortreatingneurodegenerativediseases.Thesebioactivecompounds,includingdiosgeninandtrigonelline,supportfenugreek’stherapeuticpromiseandwarrantfurtherinvitro,invivo,andclinicalstudies.Conclusion:TheSaudifenugreekcultivarisrichinbioactivecompoundswithgoodantibacterialpotential.ThesefindingsestablisharobustfoundationforcontinuedpharmacologicalresearchontheSaudicultivarofT.foenum-graecum,highlightingitspotentialasarichsourceofbioactivecompoundswithsignificantmedicinalvalue.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3---Figure4---Figure517pes,330KiB OpenAccessArticleGoingShortandGoingDigital:HowDoConsumersViewtheImpactsofDigitalizingShortFoodSupplyChains?byChrysanthiCharatsari,EvelosD.LioutasandMarcelloDeRosaSustainability2024,16(24),;doi.org/10.3390/su1(registering DOI)-21Dec2024Abstractriculturaldigitalizationandshortfoodsupplychains(SFSCs)areconsideredtobedifferentenuesfortransitioningtomoresustainablerifoodsystems.Cantheseenuesbeputtogether,oraretheyparalleland,hence,notcompatible?Theanswertothatquestionlargelydependson[...]Readmore.riculturaldigitalizationandshortfoodsupplychains(SFSCs)areconsideredtobedifferentenuesfortransitioningtomoresustainablerifoodsystems.Cantheseenuesbeputtogether,oraretheyparalleland,hence,notcompatible?TheanswertothatquestionlargelydependsonthepotentialeffectsofdigitalizationonSFSCs.Goingdigitalisatransformativeprocess,accompaniedbydesirableandundesirableeconomic,social,environmental,andculturalimpactsonshortsupplyschemes.Inthiscross-sectionalquantitativestudy,basedondatafrom211individualswhofrequentlybuyfromSFSCs,weexaminedhowconsumersevaluatetheseimpacts.Wealsoinvestigatedhowparticipants’perceptionsoftheseimpactsinfluencetheiracceptanceofriculturaldigitalizationandtheirwillingnesstobuyfoodproductsfromdigitalizedSFSCs.Ourresultsrevealedthatconsumersviewdigitalizationasasourceofpositiveenvironmentalbutadversesocial,cultural,andeconomicimpactsonshortsupplyschemes.Inaddition,wefoundthatacceptanceofdigitalizationandwillingnesstobuyfromdigitalizedSFSCsreceivedmoderate-to-lowscores.Tworegressionsshowedthatbuyers’perceptionsofthesocialimpactsthatfollowdigitalizationshapebothacceptanceandwillingness.Thesefindingsuncoveredconsumers’skepticismtowarddigitalization,suggestingthattheircommitmenttoshortsupplychainsandthevaluesthattheseschemesrepresentcultivatethebeliefthatdigitalizationcannegativelytransformSFSCs,leadingtoanunwelcomeindustrialization.Fullarticle(ThisarticlebelongstotheSpecialIssueSustainableDevelopmentGoalsandri-FoodSupplyChain)11pes,926KiB OpenAccessArticleTemporalREOver-ExpressionDisruptsLungDevelopmentbyModulatingApoptoticSignalingbyDerekM.Clarke,MadisonN.Kirkham,LoganB.Beck,CarrleighCampbell,HaydenAlcorn,BenjaminT.Bikman,JuanA.ArroyoandPaulR.ReynoldsCurr.IssuesMol.Biol.2024,46(12),-;doi.org/10.3390/cimb(registering DOI)-21Dec2024AbstractReceptorsforadvancedglycationendproducts(RE)aremultiligandcellsurfacereceptorsfoundmostabundantlyinlungtissue.ThisstudysoughttoevaluatetheroleofREinlungdevelopmentbyusingatransgenic(TG)mousemodelthatspatiallyandtemporallycontrolledRE[...]Readmore.Receptorsforadvancedglycationendproducts(RE)aremultiligandcellsurfacereceptorsfoundmostabundantlyinlungtissue.ThisstudysoughttoevaluatetheroleofREinlungdevelopmentbyusingatransgenic(TG)mousemodelthatspatiallyandtemporallycontrolledREoverexpression.HistologicalimingrevealedthatREupregulationfromembryonicday(E)15.5toE18.5ledtoathickenedalveolarparenchymaandreducedalveolarsurfacearea,whileREoverexpressionfromE0toE18.5causedasignificantlossoftissueanddecreasedarchitecture.MitochondrialdysfunctionwasahallmarkofRE-mediateddisruption,withdecreasedlevelsofanti-apoptoticBCL-Wandelevatedpro-apoptoticBID,SMAC,andHTRA2,indicatingcompromisedmitochondrialintegrityandincreasedintrinsicapoptoticactivity.Extrinsicapoptoticsignalingwassimilarlydysregulated,asevidencedbytheincreasedexpressionofTNFRSF21,Fas/FasL,andTrailR2inE0-18.5RETGmice.Additionally,reductionsinIGFBP-3andIGFBP-4,coupledwithelevatedp53anddecreasedp27expression,highlighteddisruptionsinthecellsurvivalandcycleregulatorypathways.Despitethecompensatoryupregulationofinhibitorsofapoptosisproteins(cIAP-2,XIAP,andSurvivin),tissuelossandstructuraldamepersisted.ThesefindingsunderscoreRE’sroleasapivotalmodulatoroflungdevelopment.Specifically,thetimingofREupregulationsignificantlyimpactslungdevelopmentbyinfluencingpathwaysthatcausedistincthistologicalphenotypes.ThisresearchmayforeshadowhowREsignalingplausiblycontributestodevelopmentallungdiseases.Fullarticle(ThisarticlebelongstotheSectionBiochemistry,MolecularandCellularBiology)attachmentSupplementarymaterial:SupplementaryFile1(ZIP,126KiB)18pes,1163KiB OpenAccessArticleProspectiveEvaluationofthePrevalenceandLaboratoryFindingsinAdultCatswithLowThyroxineandIncreasedThyrotropinConcentrationbyJoannaLin,ChristinaSchwens,NataliBauerandKatarinaHazuchovaPets2024,1(3),500-517;doi.org/10.3390/pets(registering DOI)-21Dec2024AbstractAdult-onsetspontaneousfelinehypothyroidism(SH)isconsideredrare,butitsprevalenceisunknown.ThisstudyaimedtoscreenlaboratorysubmissionsforcatswithlaboratorysuspectedSH(LSSH)andtoidentifylaboratoryabnormalitiesassociatedwithLSSH.SubmissionstoacommerciallaboratoryinGermanybetween[...]Readmore.Adult-onsetspontaneousfelinehypothyroidism(SH)isconsideredrare,butitsprevalenceisunknown.ThisstudyaimedtoscreenlaboratorysubmissionsforcatswithlaboratorysuspectedSH(LSSH)andtoidentifylaboratoryabnormalitiesassociatedwithLSSH.SubmissionstoacommerciallaboratoryinGermanybetweenJanuary2022andApril2023wereprospectivelyscreenedforcatsed3–12yearswithlowtotalthyroxine(TT4);inthesecats,thyrotropin(TSH)wasmeasured.Iatrogenichypothyroidismwasexcludedbycontactingsubmittingveterinarians.Creatinine,triglycerideandcholesterolconcentrationandredbloodcellcount(RBC)ofcatswithLSSH(lowTT4,TSH>0.53ng/mL;i.e.,[onesidedTSHreferencechangevalue(76%)ofTSHupperreferenceinterval(RI)]+[TSHupperRI]=0.53)werecomparedtoeuthyroidcats(TT4withinRI)andcatswithsuspectednon-thyroidalillness(SNTIS)(lowTT4,normalTSH(<0.3ng/mL;upperRI))bynon-parametrictests.p<0.05wassignificant.Intotal,31,572submissionsofcatswereincluded,25,169(79.7%)wereeuthyroid,3818(12.1%)hadSNTISand61(0.2%)hadLSSH.CatswithLSSHhadhighercreatinine(p=0.002)andlowerRBCcount(p<0.0001)thaneuthyroidcatsaswellashighercreatinine(p=0.)thancatswithSNTIS.Azotaemia(creatinine>140µmol/L)andanaemia(RBC<7.2×1012/L)werepresentin28/49(57%)and19/44(43%)catswithLSSH,respectively.TherewasnodifferencebetweenLSSHandSNTISfortheremainingparameters.IncatswithlowTT4,azotaemiaandanaemiamightindicatethepresenceofSHandreinforcetheneedforTSHtesting.HypercholesterolaemiaandhypertriglyceridaemiaarenotindicatorsofSH.Fullarticle9658;9660;ShowFiguresFigure1Figure2---Figure3attachmentSupplementarymaterial:SupplementaryFile1(ZIP,1330KiB)14pes,6584KiB OpenAccessArticleTheRoleofCurcumininPreventingNaturallyOccurringLeiomyomaintheGallineModelbyKazimSahin,CemalOrhan,MehmetTuzcu,NurhanSahin,IbrahimH.Ozercan,NashwaKabil,OmerKucukandBulentOzpolatPharmaceuticals2024,17(12),1732;doi.org/10.3390/ph(registering DOI)-21Dec2024AbstractBackground:Leiomyoma(LM)isthemostcommonlyidentifiedtumorinthegenitaltract,occurringin70–80%ofwomen.Theonlytreatmentoptionissurgery,whichsignificantlyinfluenceshealthcarecostsandnegativelyinfluenceswomen’ssurvivalandreproductivecapacity.Therefore,identifyingsafeandeffectivechemopreventive[...]Readmore.Background:Leiomyoma(LM)isthemostcommonlyidentifiedtumorinthegenitaltract,occurringin70–80%ofwomen.Theonlytreatmentoptionissurgery,whichsignificantlyinfluenceshealthcarecostsandnegativelyinfluenceswomen’ssurvivalandreproductivecapacity.Therefore,identifyingsafeandeffectivechemopreventiveandtreatmentmodalitiesisneeded.Methods:Weinvestigatedtheeffectsof12monthsofdailycurcumin(0,25.8,and53mg/kg)dietontheincidenceandgrowthofspontaneouslydevelopingLMtumorsinagalline(hen)model.Results:LMtumorsweredetectedin58.9%(53/90)ofthecontrolhensasspontaneousoccurrences,whiletheywereobservedin37.7%(34/90)and24.5%(22/90)ofhenstreatedwithdailydosesof25.8mgor53.0mg,respectively,over12months.ThisreducedLMdevelopmentby35%and58.5%,respectively(p=0.004).Wealsoobservedadose-dependentinhibitionofLM-tumorgrowthandNF-κB,mTOR,p70S6K1,and4E-BP1signalingwhileinducingNrf2/HO1pathwayinductionLMtumorscollectedfromhensfedwithcurcumin(p<0.05).CurcuminintakenotablyreducedlevelsofTGF-β1,α-SMA,andcollentype1,withdose-dependenteffects(p<0.001).Conclusions:ThefindingssuggestthatdailycurcuminconsumptionsignificantlyreducestheincidenceofnaturallyoccurringLMsandsuppressestumorgrowth.ThisindicatesthatregularcurcuminintakemaybeaneffectivepreventivemeasureainstLMs.Fullarticle(ThisarticlebelongstotheSpecialIssueNaturalCompoundsasPotentialAnticancer,Anti-inflammatoryandAntioxidantentsinMedicine)9658;9660;ShowFiguresGraphicalabstractFigure1---Figure2---Figure3---Figure4---Figure5---Figure6---Figure7MoreArticles...OpenAccessJournalsAcousticsActaMicrobiologicaHellenica(AMH)ActuatorsAdministrativeSciencesAdolescentsAdvancesinRespiratoryMedicine(ARM)AerobiologyAerospacericultureriEngineeringrochemicalsronomyAIAirAlgorithmsAllergiesAlloysAnalyticaAnalyticsAnatomiaAnesthesiaResearchAnimalsAntibioticsAntibodiesAntioxidantsAppliedBiosciencesAppliedMechanicsAppliedMicrobiologyAppliedNanoAppliedSciencesAppliedSystemInnovation(ASI)AppliedChemAppliedMathAquacultureJournalArchitectureArthropodaArtsAstronomyAtmosphereAtomsAudiologyResearchAutomationAxiomsBacteriaBatteriesBehioralSciencesBeveresBigDataandCognitiveComputing(BDCC)BioChemBioengineeringBiologicsBiologyBiologyandLifeSciencesForumBiomassBiomechanicsBioMedBiomedicinesBioMedInformaticsBiomimeticsBiomoleculesBiophysicaBiosensorsBioTechBirdsBlockchainsBrainSciencesBuildingsBusinessesCCancersCardiogeneticsCatalystsCellsCeramicsChallengesChemEngineeringChemistryChemistryProceedingsChemosensorsChildrenChipsCivilEngCleanTechnologies(CleanTechnol.)ClimateClinicalandTranslationalNeuroscience(CTN)ClinicalBioenergeticsClinicsandPracticeClocks&SleepCoastsCoatingsColloidsandInterfacesColorantsCommoditiesComplicationsCompoundsComputationComputerSciences&MathematicsForumComputersCondensedMatterConservationConstructionMaterialsCorrosionandMaterialsDegradation(CMD)CosmeticsCOVIDCropsCryoCryptographyCrystalsCurrentIssuesinMolecularBiology(CIMB)CurrentOncologyDairyDataDentistryJournalDermatoDermatopathologyDesignsDiabetologyDinosticsDieteticsDigitalDisabilitiesDiseasesDiversityDNADronesDrugsandDrugCandidates(DDC)DynamicsEarthEcologiesEconometricsEconomiesEducationSciencesElectricityElectrochemElectronicMaterialsElectronicsEmergencyCareandMedicineEncyclopediaEndocrinesEnergiesEnergyStoreandApplications(ESA)EngEngineeringProceedingsEntropyEnvironmentalandEarthSciencesProceedingsEnvironmentsEpidemiologiaEpigenomesEuropeanBurnJournal(EBJ)EuropeanJournalofInvestigationinHealth,PsychologyandEducation(EJIHPE)FermentationFibersFinTechFireFishesFluidsFoodsForecastingForensicSciencesForestsFossilStudiesFoundationsFractalandFractional(FractalFract)FuelsFutureFutureInternetFuturePharmacologyFutureTransportationGalaxiesGamesGasesGastroenterologyInsightsGastrointestinalDisordersGastronomyGelsGenealogyGenesGeographiesGeoHazardsGeomaticsGeometryGeosciencesGeotechnicsGeriatricsGlaciesGout,Urate,andCrystalDepositionDisease(GUCDD)GrassesHardwareHealthcareHeartsHematoHematologyReportsHeriteHistoriesHorticulturaeHospitalsHumanitiesHumansHydrobiologyHydrogenHydrologyHygieneImmunoInfectiousDiseaseReportsInformaticsInformationInfrastructuresInorganicsInsectsInstrumentsIntelligentInfrastructureandConstructionInternationalJournalofEnvironmentalResearchandPublicHealth(IJERPH)InternationalJournalofFinancialStudies(IJFS)InternationalJournalof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